(2,3-Difluorophenyl)boronic acid → 2-(2,3-Difluorobiphenyl-4'-yl)-5-octyl-1,3-dioxane

HRID 2292442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2292442
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[O:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][O:9]2)=[CH:4][CH:3]=1.[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[O:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][O:9]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 2734333(2,3-Difluorophenyl)boronic acidHCID 129249672-(4'-Bromophenyl)-5-n-octyl-1,3-dioxane

Produkt 1

HCID 214779752-(2,3-Difluorobiphenyl-4'-yl)-5-octyl-1,3-dioxane

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 10340Sodium CarbonateLösungsmittel

Versuchsvorschrift

Quantities: compound from Example 14 (10.7 g, 30 mmol), compound from Example 36 (5.5 g, 35 mmol), tetrakis(triphenylphosphine)palladium(0) (1.04 mg, 0.9 mmol) and aqueous sodium carbonate (30 cm3, 2M). The experimental procedure was as described in Example 63.

Quellen und Nachweise

ORD-Eintrag
ord-9ac42e18da964919bfa8e3fc5ce013b9
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05683623

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