4-oxo-4H-1-benzopyran-2-carbonyl chloride → 2-Benzoyl-4H-1-benzopyran-4-one

HRID 2292626Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2292626
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[CH:3]=[C:2]1[C:12](Cl)=[O:13].[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[C:12]([C:2]1[O:1][C:10]2[C:5]([C:4](=[O:11])[CH:3]=1)=[CH:6][CH:7]=[CH:8][CH:9]=2)(=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 787884-oxo-4H-1-benzopyran-2-carbonyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 127520732-Benzoyl-4H-1-benzopyran-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Combine chromone-2-carboxylic acid chloride (2.0 g, 9.6 mmol) and aluminum chloride (3.84 g, 28.7 mmol) in benzene (70 mL). Heat at reflux for 4 hours. Pour the reaction mixture into ice-water (150 mL). Extract with dichloromethane twice. Dry the separated organic layers over MgSO4, filter, and evaporate in vacuo. Chromatograph on silica gel eluting with 15% ethyl acetate/hexane. Evaporate the product containing fractions to give the title compound as a solid.

Aufarbeitung

  1. temperatureHeat
  2. temperatureat reflux for 4 hours
  3. extractionExtract with dichloromethane twice
  4. dry with materialDry the separated organic layers over MgSO4
  5. filtrationfilter
  6. customevaporate in vacuo
  7. customEvaporate the product
  8. additioncontaining fractions

Quellen und Nachweise

ORD-Eintrag
ord-3355e4999d794acdbd765d8725b5597a
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05684017

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