3-Phenylprop-2-enenitrile → N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylsulfonylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

HRID 229334

Reaktionsgleichung

Reaktionsgleichung von HRID 229334
[C:1](#[N:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH2:17])[CH:13]=1.[CH3:18][S:19]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:21])=[O:20]>>[CH3:11][C:12]1[NH:16][N:15]=[C:14]([NH:17][C:3]2[CH:2]=[C:1]([N:25]3[CH2:26][CH2:27][N:22]([S:19]([CH3:18])(=[O:21])=[O:20])[CH2:23][CH2:24]3)[N:10]=[C:1]([CH:2]=[CH:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:10]=2)[CH:13]=1

Komponenten

4

Edukt 3

HCID 746673-Phenylprop-2-enenitrileHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 7091611-(Methylsulfonyl)piperazine

Produkt 1

HCID 66738751N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylsulfonylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

Versuchsvorschrift

Example 71 was synthesized via Scheme 6 according to the general scheme provided above with the appropriate starting materials cinnamonitrile, 5-methyl-1H-pyrazole-3-amine, and 4-methylsulfonylpiperazine. Structure of the target was confirmed by 1H-NMR. The 1H-NMR is attached.

Aufarbeitung

  1. customExample 71 was synthesized via Scheme 6 according to the general scheme
  2. customprovided above with the

Quellen und Nachweise

ORD-Eintrag
ord-834453af306b4f01ae5cfaeeb7515650
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07563787B2

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