Acetone → HCID 21476885, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH:6]1[O:10][C:9]([NH2:11])=[N:8][CH2:7]1.[CH3:16][C:17]([CH3:19])=O>>[CH2:16]([NH:11][C:9]1[O:10][CH:6]([CH2:5][O:4][C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=2[CH3:1])[CH2:7][N:8]=1)[CH2:17][CH3:19]Komponenten
3
Versuchsvorschrift
In a reactor are introduced 0,01 mol of 5-[(2-methylphenoxy)methyl]-4,5-dihydro-oxazol-2-ylamine and 100 ml of acetone. Once dissolution is complete, 0,005 mol of 1-bromopropyl are added and the whole is heated to ebullition during 48 hours. After filtering off the formed solid and evaporating the solvent, the crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5).
Aufarbeitung
- dissolutionOnce dissolution
- addition0,005 mol of 1-bromopropyl are added
- temperaturethe whole is heated
- filtrationAfter filtering off the formed solid
- customevaporating the solvent
- customthe crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5)