Hydrochloric Acid → HCID 21473349, Verbindung

HRID 2293992

Reaktionsgleichung

Reaktionsgleichung von HRID 2293992
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:20])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO>[ClH:21].[OH:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][NH:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 214733471-t-Butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine

Produkt 1

HCID 21473349HCID 21473349, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

In 100 ml of methanol was dissolved 2.4 g (0.0086 mole) of 1-t-butoxycarbonyl-3-hydroxy-4-phenylaminopyrrolidine obtained as described above, and 30 ml of 6N hydrochloric acid was added thereto. After the mixture was refluxed by heating for 2.5 hours, the solvent was removed under reduced pressure. The resulting residue was washed with ethanol and ether to obtain 1.52 g of 3-hydroxy-4-phenylaminopyrrolidine hydrochloride as light brown powder.

Aufarbeitung

  1. customobtained
  2. additionwas added
  3. temperatureAfter the mixture was refluxed
  4. temperatureby heating for 2.5 hours
  5. customthe solvent was removed under reduced pressure
  6. washThe resulting residue was washed with ethanol and ether

Quellen und Nachweise

ORD-Eintrag
ord-00670e6f07064619996405877f3459db
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688791

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