Hydrochloric Acid → 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride

HRID 2294007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294007
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][C:12]1[C:13]([NH2:19])=[N:14][C:15]([CH3:18])=[N:16][CH:17]=1.[ClH:20]>CO>[ClH:20].[ClH:20].[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][C:12]1[C:13]([NH2:19])=[N:14][C:15]([CH3:18])=[N:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 214736575-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine

Produkt 1

HCID 214737105-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochlorideAusbeute 40,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 0.70 g (0.00275 mol) of 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine in 15 ml of methanol was treated with 0.85 ml (0.00435 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol. 0.29 g (32%) of 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 260°-265°.

Aufarbeitung

  1. customthe residue was recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-071234b36ec148a19f53415b5c74fcd9
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688798

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