Hydrochloric Acid → 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride

HRID 2294009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294009
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1.[ClH:26]>C(O)C>[ClH:26].[ClH:26].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:19][CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:16]=3)[CH2:11]2)=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 98623392-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine

Produkt 1

HCID 214737112-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochlorideAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 0.177 g (0.00053 mol) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl )-pyrimidin-4-ylamine in 20 ml of ethanol was treated with 0.15 ml (0.000525 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.10 g (47%) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 212°-214°.

Aufarbeitung

  1. customthe residue was recrystallized from ethanol/diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-aa119e3e72dc4c73b0141cc73f0aba92
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688798

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