Hydrochloric Acid → 2-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride

HRID 2294027Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294027
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[ClH:24]>CO>[ClH:24].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:14][CH2:15]2)=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 214736142-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine

Produkt 1

HCID 214737132-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochlorideAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 0.37 g (0.0012 mol) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine in 20 ml of methanol was treated with 0.37 ml (0.00129 mol) of 3.5N ethanolic hydrochloric acid, The solution was completely freed from the solvents and the residue was recrystallized from ethanol. 0.36 g (87%) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride (1:1.2) was obtained as white crystals; m.p. 240°-242°.

Aufarbeitung

  1. customthe residue was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-00c4f20c742949b193696e7c20ead8da
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688798

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