Hydrochloric Acid → 5-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294033Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294033
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 214736725-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

Produkt 1

HCID 214737025-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochlorideAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

0.17 g (0.00059 mol) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 120 ml of hot methanol. The solution was treated at room temperature with 0.32 ml (0.00118 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.21 g (71%) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as white crystals; m.p. 275°-277°.

Aufarbeitung

  1. customthe residue was recrystallized from methanol/diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-945448211fc845539079e982daa62383
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688798

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