Hydrochloric Acid → 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294037

Reaktionsgleichung

Reaktionsgleichung von HRID 2294037
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[ClH:23]>CO>[ClH:23].[ClH:23].[C:1]1([CH3:22])[CH:2]=[CH:3][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 214736335-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

Produkt 1

HCID 214736325-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochlorideAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

0.23 g (0.00077 mol) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 220 ml of hot methanol. The solution was treated at room temperature with 0.44 ml (0.00154 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.22 g (77%) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as whited crystals; m.p. 220°-222°.

Aufarbeitung

  1. customthe residue was recrystallized from ethanol/diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-60f3192f14224afc936563c5caeac9ae
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688798

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