Ammonia → HCID 21474075, Verbindung

HRID 2294192Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294192
[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([Br:15])=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH3:16]>CO>[NH2:1][C:2]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([Br:15])=[CH:8][C:3]=1[C:4]([NH2:16])=[O:5]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 21474098HCID 21474098, Verbindung

Produkt 1

HCID 21474075HCID 21474075, VerbindungAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

25.8 g (93.8 mmol) of methyl 2-amino-5-bromo-4-nitro-benzoate were dissolved in 800 ml of methanol and saturated with ammonia at -40° C. Subsequently, the mixture was stirred at room temperature overnight. The solution was concentrated and the residue was triturated with methylene chloride. The precipitate was filtered off under suction and dried. 18.3 g (75%) of 2-amino-5-bromo-4-nitro-benzamide were obtained as orange coloured crystals;

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customthe residue was triturated with methylene chloride
  3. filtrationThe precipitate was filtered off under suction
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9b69b947b99b4ce18f1093ce412613ad
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688803

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