Trifluoroacetate → 5-hydroxy-8-{1-hydroxy-2-[1-(4-hydroxy-benzyl)-cyclopropylamino]-ethyl}-4H-benzo[1,4]oxazin-3-one
Reaktionsgleichung
C([O:8][C:9]1[C:14]2[NH:15][C:16](=[O:19])[CH2:17][O:18][C:13]=2[C:12]([C:20](=[O:24])[CH:21](O)O)=[CH:11][CH:10]=1)C1C=CC=CC=1.C([O:32][C:33]1[CH:43]=[CH:42][C:36]([CH2:37][C:38]2([NH2:41])[CH2:40][CH2:39]2)=[CH:35][CH:34]=1)C1C=CC=CC=1.FC(F)(F)C([O-])=O>>[OH:8][C:9]1[C:14]2[NH:15][C:16](=[O:19])[CH2:17][O:18][C:13]=2[C:12]([CH:20]([OH:24])[CH2:21][NH:41][C:38]2([CH2:37][C:36]3[CH:42]=[CH:43][C:33]([OH:32])=[CH:34][CH:35]=3)[CH2:40][CH2:39]2)=[CH:11][CH:10]=1Komponenten
4
Versuchsvorschrift
Prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 253 mg (1 mmol) 1-(4-benzyloxy-benzyl)-cyclopropylamine. Yield: 20 mg (4%, trifluoroacetate); mass spectroscopy: [M+H]+=371.