Thionyl Chloride → 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetyl chloride

HRID 2294538

Reaktionsgleichung

Reaktionsgleichung von HRID 2294538
[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15](O)=[O:16])[CH:5]=[CH:4][C:3]1=2.S(Cl)([Cl:21])=O>>[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]([Cl:21])=[O:16])[CH:5]=[CH:4][C:3]1=2

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 181779322-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetic acid

Produkt 1

HCID 214744835,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetyl chloride

Versuchsvorschrift

6.6 g (26.8 mmol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid and 20 ml of thionyl chloride are heated to reflux until gaseous evolution has ceased. The mixture is evaporated to dryness and 7.1 g (100%) of the crude acid chloride are obtained, which product is used for the next step of the synthesis without further treatment.

Aufarbeitung

  1. temperatureto reflux until gaseous evolution
  2. customThe mixture is evaporated to dryness and 7.1 g (100%) of the crude acid chloride
  3. customare obtained
  4. customwhich product is used for the next step of the synthesis without further treatment

Quellen und Nachweise

ORD-Eintrag
ord-abbee49a6f3b4bbbb49b62df75652beb
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688817

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