Diethyl [(thiophen-3-yl)methyl]propanedioate → HCID 67723767, Verbindung
Reaktionsgleichung
[C:1]([S:5]([CH2:8][CH:9]([CH2:15][C:16]1[CH:20]=[CH:19][S:18][CH:17]=1)[C:10]([O:12]CC)=[O:11])(=[O:7])=[O:6])([CH3:4])([CH3:3])[CH3:2].S1C=CC(CC(C(OCC)=O)C(OCC)=O)=C1>>[C:1]([S:5]([CH2:8][C@@H:9]([CH2:15][C:16]1[CH:20]=[CH:19][S:18][CH:17]=1)[C:10]([OH:12])=[O:11])(=[O:7])=[O:6])([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
This compound was prepared analogously to Example 1 by the enzymatic hydrolysis of ethyl (RS)-α-[(tert-butylsulphonyl)methyl]-3-thiophenepropionate which, in turn, was prepared starting from diethyl 3-thienylmethylmalonate [J. Am. Chem. Soc. 76, 4466 (1954)] analogously to the synthesis of ethyl (RS)-α-[(tert-butylsulphonyl)methyl]hydrocinnamate described in EPA 0236734, MS: 318 (M)+.
Aufarbeitung
- customwas prepared
Quellen und Nachweise
- ORD-Eintrag