HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 2-(Piperidin-4-yloxy)pyrimidine hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 2-Chloropyrimidine | HCID 74404 | — |
| Edukt | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Edukt | Tert-butyl 4-(pyrimidin-2-yloxy)piperidine-1-carboxylate | HCID 22591437 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-(Piperidin-4-yloxy)pyrimidine hydrochloride | HCID 22591438 | — |
Reaktionsschritte
60% Sodium hydride (0.232 g) was gradually added to a tetrahydrofuran (4.5 ml) solution containing 1-tert-butoxycarbonyl-4-hydroxypiperidine (0.900 g) and 2-chloropyrimidine (0.666 g), and 2 hours later, dimethyl sulfoxide (1.0 ml) was added thereto, and the mixture was stirred at room temperature for 1 day to undergo reaction, thereby obtaining 1-tert-butoxycarbonyl-4-(2-pyrimidinyloxy)piperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(2-pyrimidinyloxy)piperidine.hydrochloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06849622B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-ba1830e01ff047e88529e7be4820093b |
| Quellennotiz | uspto-grants-2005_02 |