Hydrochloric Acid → Methyl 4-(2-aminoethoxy)benzoate

HRID 2298163Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2298163
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][NH:13]C(=O)C(C)(C)C)=[CH:6][CH:5]=1.Cl>CCO>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][CH2:12][NH2:13])=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 538869664-[2-(2,2-Dimethyl-propionylamino)ethoxy]-benzoic acid methyl ester

Produkt 1

HCID 14097616Methyl 4-(2-aminoethoxy)benzoateAusbeute 108,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 4-[2-(2,2-dimethyl-propionylamino)-ethoxy]-benzoic Acid methyl ester (350 mg) in EtOH (6 mL) at 0° C. was added concentrated HCl (3 mL). The solution was warmed to room temperature and was concentrated in vacuo to provide the hydrochloride salt of 4-(2-amino-ethoxy)-benzoic Acid methyl ester (266 mg) as a white solid which was used in the next step without further purification.

Aufarbeitung

  1. concentrationwas concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0ba3d369e79a4792b508d15a36e2a63c
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06492412B2

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