Methylamine → HCID 57461305, Verbindung

HRID 229844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 229844
[C:1](N1C=CN=C1)([N:3]1C=CN=C1)=O.[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([S:22][C:23]2[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=2[C:25](O)=[O:26])=[CH:14]1.CN>C1COCC1>[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([S:22][C:23]2[CH:31]=[CH:30][CH:29]=[CH:28][C:24]=2[C:25]([NH:3][CH3:1])=[O:26])=[CH:14]1

Komponenten

5

Edukt 3

HCID 6329MethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 107544492-(1H-indol-3-ylsulfanyl)benzoic Acid

Produkt 1

HCID 57461305HCID 57461305, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Carbonyldiimidazole (11 mmol) was added to a solution of 2-(1H-indol-3-ylsulfanyl) benzoic acid (Hamel, P.; Girard, M.; Tsou, N. N.; J. Heterocycl. Chem. 36, 1999, 643-652) (10 mmol) in dry THF (200 mL) and refluxed for 60 minutes under argon. Methyl amine (1M in THF; 40 ml) was added slowly to the reaction mixture and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the product purified by column chromatography on silica gel using ethyl acetate as an eluent.

Aufarbeitung

  1. temperaturerefluxed for 60 minutes under argon
  2. customThe mixture was evaporated in vacuo
  3. customthe product purified by column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-49ac13a6ee2d4fe4ad336fa55ce9c015
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07563908B2

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