4-Bromophenol → 4-Bromo-2-tert-butylphenol

Reaktionsgleichung

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10](=[CH2:12])[CH3:11]>>[C:10]([C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[OH:8])([CH3:12])([CH3:11])[CH3:9]

Komponenten

Edukt 2

HCID 78084-Bromophenol

HCID 8255Isobutylene

Produkt 1

HCID 970684-Bromo-2-tert-butylphenol

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

80.00 g (426.0 mmol) of 4-bromophenol and 8.00 g of Dowex 50WX8 sulphonic acid resin are mixed in a 250 ml three-necked flask. The mixture is heated to 80° C. and a stream of isobutylene is passed through for 30 hours. The reaction mixture is cooled and the residue is purified by passing through a silica column eluted with a mixture composed of 95% dichloromethane and of 5% heptane. 88.00 g (90%) of the expected compound are collected in the form of a yellow oil.

Aufarbeitung

customis passed through for 30 hours
temperatureThe reaction mixture is cooled
customthe residue is purified
washeluted with a mixture
custom88.00 g (90%) of the expected compound are collected in the form of a yellow oil

Quellen und Nachweise

ORD-Eintrag: ord-e13260ce32574b5b9e5417084cc467b0
Quelldatensatz: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06849658B2

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