Hydrochloric Acid → HCID 178497105, Verbindung

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a 0° C. solution of methyl 1-[(trans-4-tert-butylcyclohexyl)amino]indane-5-carboxylate (0.43 g, 1.30 mmol) and DIEA (0.27 mL, 1.56 mmol) in dry dichloromethane (20 mL) was added thiophosgene (0.11 mL, 1.36 mmol) slowly. After stirring at 0° C. for 10 min and then at room temperature for 45 min, a solution of N-methylbenzene-1,2-diamine (0.38 g, 3.12 mmol) and DIEA (0.53 mL, 3.12 mmol) in dry dichloromethane (5 mL) was added. The reaction mixture was stirred for 1 h at room temperature, then diluted with dichloromethane (30 mL) and poured into aqueous HCl (1N, 30 mL). The organic layer was separated and washed with aqueous HCl (1N, 30 mL), saturated aqueous NaHCO3 (30 mL), brine (30 mL), dried over Na2SO4 and then concentrated to dryness. The residue was dissolved in dichloromethane (30 mL) and mercury (II) trifluoroacetate (0.61 g, 1.43 mmol) was added. The reaction mixture was stirred for 30 min at room temperature and then filtered through Celite. The organic solution was washed once with saturated NaHCO3 (30 mL), dried over Na2SO4 and concentrated. Chromatography (15% EtOAc in Hexane) afforded methyl 1-[(trans-4-tert-butylcyclohexyl)(1-methyl-1H-benzimidazol-2-yl)amino]indane-5-carboxylate. HPLC/MS: m/z=460.3 (M+1), Rt=3.46 min. 1H NMR (CDCl3): δ 7.85 (1H, s), 7.78 (1H, d, J=8.0 Hz), 7.71 (1H, m), 7.27 (1H, d, J=8.5 Hz), 7.25-7.18 (3H, m), 5.04 (1H, dd, J=7.5, 5.0 Hz), 3.90 (3H, s), 3.48 (3H, s), 3.24 (1H, m), 3.10 (1H, m), 2.83 (1H,

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