Thionyl Chloride → 4-Isothiocyanatobenzoyl chloride
Reaktionsgleichung
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[C:11]=[S:12])=[CH:6][CH:5]=1)(O)=[O:2].S(Cl)([Cl:15])=O>>[N:10]([C:7]1[CH:8]=[CH:9][C:4]([C:1]([Cl:15])=[O:2])=[CH:5][CH:6]=1)=[C:11]=[S:12]Komponenten
3
Versuchsvorschrift
A mixture of 500 mg (2.79 mmol) of 4-carboxyphenylisothiocyanate and 5 ml of thionyl chloride was refluxed for 6 hours. The reaction mixture was concentrated at reduced pressure and the resulting tan solid was pumped at high vacuum overnight. The solid was triturated with a small amount of hexane and collected by suction filtration to yield 516 mg (93%) of product as an off-white solid.
Aufarbeitung
- temperaturewas refluxed for 6 hours
- concentrationThe reaction mixture was concentrated at reduced pressure
- customwas pumped at high vacuum overnight
- customThe solid was triturated with a small amount of hexane
- filtrationcollected by suction filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-57092f1f27ce496cbeeb2375c53ed4c5
- Quelldatensatz
- uspto-grants-2009_07
- Patentnummer
- US07566549B2
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