Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Urea | HCID 1176 | — |
| Edukt | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Produkt | 6-iodo-1H-quinazoline-2,4-dione | HCID 11380668 | 87,4% |
Reaktionsschritte
A mixture of 2-amino-5-iodobenzoic acid (3.5 g) and urea (1.56 g) in NMP (15 ml) was heated at 160° C. for 6 hours then cooled. Water (200 ml) was added and the resultant precipitate was collected, washed with water and dried to give the title compound (3.35 g) as a solid. MS (CI): 289 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06498275B1 |
|---|
| Quelldatensatz | uspto-grants-2002_12 |
|---|
| ORD ID | ord-55b39c4db08a431c9102d98fe03163de |
|---|
| Quellennotiz | uspto-grants-2002_12 |
|---|
