3,5-Difluorophenylacetic acid → (S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline

HRID 23014

Reaktionsgleichung

Reaktionsgleichung von HRID 23014
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.[NH2:14][CH:15]([C:17]1[S:18][CH2:19][C@H:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:21]=1)[CH3:16]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:14][CH:15]([C:17]2[S:18][CH2:19][C@H:20]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:21]=2)[CH3:16])=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1

Komponenten

3

Edukt 2

HCID 1454243,5-Difluorophenylacetic acidHCID 69741166(S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride

Produkt 1

HCID 69743302(S)-2-[1-(3,5-difluorophenylacetamido)ethyl]-4-ethoxycarbonyl-2-thiazoline

Versuchsvorschrift

Following General Procedure A above and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-4-ethoxycarbonyl-2-thiazoline hydrochloride (Example G), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.2 in 1:1 EtOAc/hexanes) and the product was purified by silica gel chromatography using 1:1 EtOAc/hexanes as the eluent.

Aufarbeitung

  1. customthe product was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4b5f11cfbb094dedbb3d02741f1c7ebc
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849650B2

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