HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,5-Difluorophenylacetic acid → (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| Edukt | (s)-2-(1-Aminoethyl)-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723742 | — |
| Lösungsmittel | Chloroform methanol | HCID 21584188 | — |
| Produkt | (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723741 | — |
Reaktionsschritte
Following General Procedure A and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-5(R,S)-ethoxycarbonyl-2-oxazoline (Example F), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.3 in 5% MeOH/CHCl3) and the product was purified by silica gel chromatography using 5% MeOH/CHCl3 as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06849650B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-c299ca4730364ed6b87f71d07b1e409a |
| Quellennotiz | uspto-grants-2005_02 |