Methyl 3-bromo-2,4,5-trifluorobenzoate → Methyl 3-cyano-2,4,5-trifluoro-benzoate

HRID 2302216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2302216
Br[C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6].[Cu](C#N)[C:16]#[N:17]>CN(C)C=O>[C:16]([C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6])#[N:17]

Komponenten

4

Edukt 2

HCID 18459836Methyl 3-bromo-2,4,5-trifluorobenzoateHCID 178418260HCID 178418260, Verbindung

Produkt 1

HCID 18417526Methyl 3-cyano-2,4,5-trifluoro-benzoateAusbeute 66,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

269 g of methyl 3-bromo-2,4,5-trifluoro-benzoate and 108 g of copper cyanide are heated to reflux for 5 hours in 400 ml of dimethylformamide. All volatile constituents of the reaction mixture are then removed by distillation in vacuo. The distillate is then fractionated on a column. 133 g of methyl 3-cyano-2,4,5-trifluoro-benzoate of boiling point 88-89° C./0.01 mbar are obtained.

Aufarbeitung

  1. customAll volatile constituents of the reaction mixture are then removed by distillation in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6d38a5a90ccc4e8ea63e9a23134ed107
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06432948B1

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