1-Methylpiperazine → N-[2-chloro-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamide

HRID 2302271

Reaktionsgleichung

Reaktionsgleichung von HRID 2302271
Cl[C:2]1[CH:7]=[C:6]([C:8]([NH:10][C:11]2[CH:16]=[C:15]([NH:17][C:18]([C:20]3[CH:25]=[CH:24][N:23]=[C:22]([N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)[CH:21]=3)=[O:19])[CH:14]=[CH:13][C:12]=2[Cl:32])=[O:9])[CH:5]=[CH:4][N:3]=1.[CH3:33][N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[Cl:32][C:12]1[CH:13]=[CH:14][C:15]([NH:17][C:18]([C:20]2[CH:25]=[CH:24][N:23]=[C:22]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)[CH:21]=2)=[O:19])=[CH:16][C:11]=1[NH:10][C:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:37]2[CH2:38][CH2:39][N:34]([CH3:33])[CH2:35][CH2:36]2)[CH:7]=1)=[O:9]

Komponenten

3

Edukt 2

HCID 531671-MethylpiperazineHCID 220579822-chloro-N-[2-chloro-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]pyridine-4-carboxamide

Produkt 1

HCID 22057954N-[2-chloro-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]-2-(4-methylpiperazin-1-yl)pyridine-4-carboxamideAusbeute 69 %

Versuchsvorschrift

Using an analogous procedure to that described in Example 21, 2-chloro-N-[2chloro-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]pyridine-4-carboxamide was reacted with N-methylpiperazine to give the title compound in 69% yield; NMR Spectrum: (DMSOd6) 2.21 (s, 3H), 2.4 (m, 4H), 3.53 (m, 8H), 3.71 (m, 4H), 7.09 (m, 2H), 7.25 (d, 2H), 7.53 (d, 1H), 7.71 (d, 1H), 8.02 (s, 1H), 8.26 (t, 1H), 10.19 (s, 1H), 10.48 (s, 1H); Mass Spectrum: M+H+ 536.

Quellen und Nachweise

ORD-Eintrag
ord-a362af07a0dc46c2a27c98daf1f1552e
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06432949B1

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