1-methyl-1H-Imidazole-5-carbonyl chloride → 1-(3-Methyl-3H-imidazol-4-yl)-2-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-yl)-ethanone

HRID 230262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 230262
CO[C:3](=[O:22])[CH2:4][C:5]1[N:9]2[CH:10]=[C:11]([CH3:14])[CH:12]=[CH:13][C:8]2=[N:7][C:6]=1[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1.[CH3:23][N:24]1[C:28](C(Cl)=O)=[CH:27][N:26]=[CH:25]1>>[CH3:23][N:24]1[C:28]([C:3](=[O:22])[CH2:4][C:5]2[N:9]3[CH:10]=[C:11]([CH3:14])[CH:12]=[CH:13][C:8]3=[N:7][C:6]=2[C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)=[CH:27][N:26]=[CH:25]1

Komponenten

3

Edukt 2

HCID 27765541-methyl-1H-Imidazole-5-carbonyl chlorideHCID 9839075Methyl 2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetate

Produkt 1

HCID 113937981-(3-Methyl-3H-imidazol-4-yl)-2-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-yl)-ethanone

Versuchsvorschrift

Prepared from (6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetic acid methyl ester 35a and 3-methyl-3H-imidazole-4-carbonyl chloride using the procedure of Method C described above. 1H NMR (400 MHz, CDCl3) δ2.34 (s, 3H), 2.39 (s, 3H), 3.91 (s, 3H), 4.52 (s, 2H), 7.05 (dd, J=1.1, 9.1 Hz, 1H), 7.26 (m, 2H), 7.57 (m, 4H), 7.74 (s, 1H), 7.80 (s, 1H). Mass spectrum (m/e) 345 (M+).

Quellen und Nachweise

ORD-Eintrag
ord-bf907e98fc7b439f96e88c6ecd46efc3
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566725B2

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