5-Bromoindole → 5-Bromo-1-methyl-1H-indole

Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.Br[C:12]1C=CC=C2C=1N(C)C=C2.BrC1C=CC=C2C=1NC=C2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:12])[CH:6]=[CH:5]2

Komponenten

Edukt 3

HCID 249055-Bromoindole

HCID 27570207-Bromoindole

HCID 219500697-Bromo-1-methyl-1H-indole

Produkt 1

HCID 2857575-Bromo-1-methyl-1H-indole

Versuchsvorschrift

5-Bromo-1-methylindole was prepared from 5-bromoindole as described for the preparation of 7-bromo-1-methylindole from 7-bromoindole. Purification by chromatography using EtOAc:petroleum ether 1:10

Aufarbeitung

customPurification by chromatography

Quellen und Nachweise

ORD-Eintrag: ord-11e7f7713be74a2c9c1624301c833944
Quelldatensatz: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06432962B1

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