HCID 18461418, Verbindung → 5-{4-[6-(3,5-Di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

HRID 2303802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2303802
[O:1]=[C:2]1[NH:6][C:5](=[O:7])[CH:4]([CH2:8][C:9]2[CH:50]=[CH:49][C:12]([O:13][CH2:14][C:15]([NH:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][C:25]4[CH:30]=[C:29]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:28]([OH:35])=[C:27]([C:36]([CH3:39])([CH3:38])[CH3:37])[CH:26]=4)=[CH:20][C:19]=3[N:40]([CH3:48])C(=O)OC(C)(C)C)=O)=[CH:11][CH:10]=2)[S:3]1.[ClH:51].O1CCOCC1>>[ClH:51].[C:36]([C:27]1[CH:26]=[C:25]([CH:30]=[C:29]([C:31]([CH3:32])([CH3:34])[CH3:33])[C:28]=1[OH:35])[O:24][C:21]1[CH:22]=[CH:23][C:18]2[N:17]=[C:15]([CH2:14][O:13][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH:4]4[S:3][C:2](=[O:1])[NH:6][C:5]4=[O:7])=[CH:50][CH:49]=3)[N:40]([CH3:48])[C:19]=2[CH:20]=1)([CH3:39])([CH3:38])[CH3:37]

Komponenten

3

Edukt 2

HCID 18461418HCID 18461418, VerbindungHCID 204431481,4-Dioxane hydrochloride

Produkt 1

HCID 867584465-{4-[6-(3,5-Di-t-butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

Versuchsvorschrift

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3,5-di-t-butyl-4-hydroxyphenoxy)phenyl}-N-methylcarbamate (0.72 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at room temperature for 17 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (0.41 g).

Aufarbeitung

  1. customThe solvent of the reaction mixture was evaporated to dryness
  2. additionTo the residue was added ethyl acetate
  3. custominsoluble product was isolated by filtration
  4. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-175f68421dd7418787cc934b4fdeeeda
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06432993B1

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