2-Chloro-4-fluorobenzonitrile → n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester

HRID 23039

Reaktionsgleichung

Reaktionsgleichung von HRID 23039
[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl.[CH2:12]([O:16][C:17](=[O:21])[CH:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([Cl:1])[CH:9]=1)[CH:13]([CH3:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 1090002-Chloro-4-fluorobenzonitrileHCID 862001092-Methylpropyl 2-aminopropanoate hydrochloride

Produkt 1

HCID 53791223n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester

Versuchsvorschrift

Following General Procedure AP above and using 2-chloro-4-fluorobenzonitrile (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example AA above), the title compound was prepared. The product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant.

Aufarbeitung

  1. customThe product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant

Quellen und Nachweise

ORD-Eintrag
ord-a4bbed5dd2044f3fadb7ea98748fef7c
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849650B2

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