Phosphorus oxychloride → 1-Chloro-7-methoxyisoquinoline

HRID 2304296Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2304296
Cl.[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][N+:10]([O-])=[CH:11]2)=[CH:6][CH:5]=1.P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:11]1[C:12]2[C:7](=[CH:6][CH:5]=[C:4]([O:3][CH3:2])[CH:13]=2)[CH:8]=[CH:9][N:10]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 226656837-Methoxy-isoquinoline-N-oxide hydrochloride

Produkt 1

HCID 222501811-Chloro-7-methoxyisoquinoline

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

7-Methoxy-isoquinoline-N-oxide hydrochloride (38.2 g) was added in portions to phosphoryl chloride (275 mL) and the mixture heated at 90° C. for 6 h. Excess of phosphoryl chloride was removed in vacuo. The remaining white solid was washed with water, filtered and dried in vacuo.

Aufarbeitung

  1. customExcess of phosphoryl chloride was removed in vacuo
  2. washThe remaining white solid was washed with water
  3. filtrationfiltered
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3efc43c5009b47909fc38669bd0e214b
Quelldatensatz
uspto-grants-2002_08
Patentnummer
US06432955B1

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