Ammonia → 7-nitro-1H-indole-2-carboxamide

HRID 230567Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 230567
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13]([O:15]CC)=O)=[CH:9]2)([O-:3])=[O:2].[NH3:18]>>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13]([NH2:18])=[O:15])=[CH:9]2)([O-:3])=[O:2]

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 250407Ethyl 7-nitro-1H-indole-2-carboxylate

Produkt 1

HCID 473196987-nitro-1H-indole-2-carboxamide

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A suspension of 133 mg (0.57 mmol) of ethyl 7-nitroindole-2-carboxylate in 3.84 ml of 28% aqueous ammonia is heated at 50° C. for 18 h in a stoppered glass tube. The reaction medium is filtered over sintered glass. The yellow solid obtained is washed with water and with cyclohexane and then dried under vacuum. 70 mg of 7-nitro-1H-indole-2-carboxamide are obtained in the form of a yellow solid.

Aufarbeitung

  1. filtrationThe reaction medium is filtered over sintered glass
  2. customThe yellow solid obtained
  3. washis washed with water and with cyclohexane
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-aa1ca6611c304af49a226cf2de84133b
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566736B2

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