Ethyl isocyanate → HCID 15871432, Verbindung

HRID 23058

Reaktionsgleichung

Reaktionsgleichung von HRID 23058
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[N:6]1([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:10][CH2:9][CH2:8][CH2:7]1>C(Cl)(Cl)Cl>[CH2:1]([NH:3][C:4]([NH:14][CH2:13][CH2:12][CH2:11][N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 8022Ethyl isocyanateHCID 316701-Pyrrolidinepropanamine

Produkt 1

HCID 15871432HCID 15871432, VerbindungAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 27.7 g (0.39 mol) ethyl isocyanate in 250 mL chloroform was added 50 g (0.39 mol) 3-(1-pyrrolidinyl)propylamine dropwise with cooling. Once the addition was complete, the cooling bath was removed and the reaction mixture stirred at room temperature for 4 hours. The reaction mixture was then concentrated under reduced pressure to give 74.5 g (96.4%) of the desired urea as a clear oil.

Aufarbeitung

  1. temperaturewith cooling
  2. additionOnce the addition
  3. customthe cooling bath was removed
  4. concentrationThe reaction mixture was then concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-592ba205f2284c8a92152d6f0b997396
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849650B2

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