Ethyl isocyanate → N-ethyl-N'-3-(1-pyrrolidinyl)propylurea
Reaktionsgleichung
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[N:6]1([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:10][CH2:9][CH2:8][CH2:7]1>C(Cl)(Cl)Cl>[CH2:1]([NH:3][C:4]([NH:14][CH2:13][CH2:12][CH2:11][N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 27.7 g (0.39 mol) ethyl isocyanate in 250 mL chloroform was added 50 g (0.39 mol) 3-(1-pyrrolidinyl)propylamine dropwise with cooling. Once the addition was complete, the cooling bath was removed and the reaction mixture stirred at room temperature for 4 hours. The reaction mixture was then concentrated under reduced pressure to give 74.5 g (96.4%) of the desired urea as a clear oil.
Aufarbeitung
- temperaturewith cooling
- additionOnce the addition
- customthe cooling bath was removed
- concentrationThe reaction mixture was then concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-592ba205f2284c8a92152d6f0b997396
- Quelldatensatz
- uspto-grants-2005_02
- Patentnummer
- US06849650B2
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