Hydrochloride methanol → N-{4-[(1R)-1-aminoethyl]-2-methylphenyl)methanesulfonamide hydrochloride

HRID 230586

Reaktionsgleichung

Reaktionsgleichung von HRID 230586
C([S@]([NH:7][C@@H:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=1)[CH3:9])=O)(C)(C)C.[ClH:22].CO>O1CCOCC1>[ClH:22].[NH2:7][C@@H:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=1)[CH3:9]

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 58640404N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide

Produkt 1

HCID 21097519N-{4-[(1R)-1-aminoethyl]-2-methylphenyl)methanesulfonamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide (530 mg, 1.60 mmol) was added HCl-methanol (2.0 M, 5.0 mL) and 1,4-dioxane (5.0 mL). The solution was stirred at room temperature for 30 minutes and then concentrated in vacuo. Diethyl ether was added to precipitate amine hydrochloride. The precipitate was then filtered and washed with diethyl ether (450 mg, quant) to furnish the title compound as a white solid.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. additionDiethyl ether was added
  3. customto precipitate amine hydrochloride
  4. filtrationThe precipitate was then filtered
  5. washwashed with diethyl ether (450 mg, quant)

Quellen und Nachweise

ORD-Eintrag
ord-a0458d0345a94e5f8c4dcca15465382a
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566739B2

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