Hydrochloric Acid → 1-(3-Morpholin-4-yl-phenyl)ethylamine hydrochloride

HRID 2307419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2307419
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:11]=1)[CH3:9])(C)(C)C.[ClH:23]>CO>[ClH:23].[N:16]1([C:12]2[CH:11]=[C:10]([CH:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 69850623[1-(3-Morpholin-4-yl-phenyl)ethyl]carbamic acid tert-butyl ester

Produkt 1

HCID 226056291-(3-Morpholin-4-yl-phenyl)ethylamine hydrochlorideAusbeute 84,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of [1-(3-morpholin-4-yl-phenyl)ethyl]carbamic acid tert-butyl ester (1 g, 3.27 mmol) in methanol (3 mL) was added hydrochloric acid (1.0 M in ethyl ether) (13.1 mL, 13.1 mmol) and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under vacuum to provide the title compound as pale yellow solid (0.67 g, quantitative yield) which was used for next step without any further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-34bafb1d17e24a42a3d1b03f22530a72
Quelldatensatz
uspto-grants-2004_12
Patentnummer
US06831080B2

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