Hexane → Methyl 3-fluoropyridine-2-carboxylate

HRID 230775

Reaktionsgleichung

Reaktionsgleichung von HRID 230775
[CH3:1]CCCCC.C[Si](C=[N+]=[N-])(C)C.[F:14][C:15]1[C:16]([C:21]([OH:23])=[O:22])=[N:17][CH:18]=[CH:19][CH:20]=1>C(O)C.CN(C=O)C>[F:14][C:15]1[C:16]([C:21]([O:23][CH3:1])=[O:22])=[N:17][CH:18]=[CH:19][CH:20]=1

Komponenten

5

Edukt 3

HCID 8058HexaneHCID 167693TrimethylsilyldiazomethaneHCID 27627863-Fluoropyridine-2-carboxylic acid

Produkt 1

HCID 26746991Methyl 3-fluoropyridine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19794673N,N-dimethylformamide ethanolLösungsmittel

Versuchsvorschrift

A hexane solution (3 mL) of 2 M trimethylsilyldiazomethane was added to a benzene/methanol mixed solvent (1/1, 12 mL) of 3-fluoropyridine-2-carboxylic acid (250 mg), and stirred at room temperature for 30 minutes. The solvent was evaporated off under reduced pressure from the reaction solution, and the resulting residue was purified through silica gel column chromatography (chloroform/methanol=40/1) to obtain the entitled compound (238 mg).

Aufarbeitung

  1. customThe solvent was evaporated off under reduced pressure from the reaction solution
  2. customthe resulting residue was purified through silica gel column chromatography (chloroform/methanol=40/1)

Quellen und Nachweise

ORD-Eintrag
ord-897de591f8e845dead7024a6fcef2167
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566781B2

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