Phosphorus oxychloride → 4,7-Dichloropyrido[2,3-d]pyrimidine

Reaktionsgleichung

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:10](O)=[N:9][CH:8]=[N:7][C:6]=2[N:12]=1.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:10]1[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[N:12][C:6]=2[N:7]=[CH:8][N:9]=1

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 178518043HCID 178518043, Verbindung

Produkt 1

HCID 226077594,7-Dichloropyrido[2,3-d]pyrimidineAusbeute 73 %

Versuchsvorschrift

A mixture of Example 140C (1 g, 5.5 mmol) in phosphorus oxychloride (40 mL) was refluxed for 2 h then cooled and evaporated. The residue was taken into ethyl acetate (75 ml), washed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml). The ethyl acetate was evaporated to yield 0.8 g of product (73%).

Aufarbeitung

temperaturethen cooled
customevaporated
washwashed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml)
customThe ethyl acetate was evaporated

Quellen und Nachweise

ORD-Eintrag: ord-2b7a77ded1d942b688d3a870805edb11
Quelldatensatz: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06831175B2

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