3-Thiophenacetic acid → 2-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

HRID 23079

Reaktionsgleichung

Reaktionsgleichung von HRID 23079
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([OH:9])=O)=[CH:2]1.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Komponenten

3

Edukt 2

HCID 234043-Thiophenacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Produkt 1

HCID 542657592-((Thien-3-yl)acetamido]butyric acid iso-butyl ester

Versuchsvorschrift

Following General Procedure BI above and using 3-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tic on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customtic on silica gel and purification
  2. filtrationwas by filtration

Quellen und Nachweise

ORD-Eintrag
ord-8b5fbc7d070540c8838cb4637750c356
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849650B2

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