Hydrochloric Acid → (3-Fluorophenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine

Beteiligte Stoffe

Reaktionsschritte

The titled compound of Example 7, 4-chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline (40 mg, 0.15 mmol) was dissolved in diisopropanol (2.5 ml), where was then added 3-fluoroaniline (33 mg, 0.3 mol) and concentrated hydrochloric acid of catalytic amount, followed by refluxing for 24 hours. Then, the reaction mixture was cooled down to a room temperature to obtain a solid, which was then filtered, washed with diisopropanol and dried under vacuum to prepare the titled compound (24 mg, 47%, m.p. 257-260° C.; mass (m/z;rel) 340.10).

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