3-Methoxyaniline → 6-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

HRID 230839Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 230839
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]([NH2:15])=[O:14].[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>C(O)C>[ClH:1].[I:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:13]([NH2:15])=[O:14])=[C:2]2[NH:21][C:20]1[CH:22]=[CH:23][CH:24]=[C:18]([O:17][CH3:16])[CH:19]=1

Komponenten

4

Edukt 2

HCID 108243-MethoxyanilineHCID 577632714-Chloro-6-iodoquinoline-3-carboxamide

Produkt 1

HCID 674246056-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Intermediate 13 (5.0 g) was dissolved in ethanol (60 ml), 3-methoxyaniline (3.37 ml) (available from Aldrich) was added, and the mixture was heated under reflux for 2.5 h. The resulting precipitate was filtered off and washed with ether to give the title compound.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2.5 h
  3. filtrationThe resulting precipitate was filtered off
  4. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-37f88493502743c4a8b42cda0fa94fe9
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566786B2

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