2-Methyl-4-(trimethylstannyl)pyridine → 5-Methyl-thiophene-2-carboxylic acid [4-methoxy-7-(2-methyl-pyridin-4-yl)-benzothiazol-2-yl]-amide

HRID 2308459Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2308459
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:14])[S:11][C:7]=2[C:6](I)=[CH:5][CH:4]=1.[CH3:22][C:23]1[CH:28]=[C:27]([Sn](C)(C)C)[CH:26]=[CH:25][N:24]=1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:13]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:14])[S:11][C:7]=2[C:6]([C:27]2[CH:26]=[CH:25][N:24]=[C:23]([CH3:22])[CH:28]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 126913202-Methyl-4-(trimethylstannyl)pyridineHCID 865849065-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide

Produkt 1

HCID 101113105-Methyl-thiophene-2-carboxylic acid [4-methoxy-7-(2-methyl-pyridin-4-yl)-benzothiazol-2-yl]-amideAusbeute 50 %

Versuchsvorschrift

5-Methyl-thiophene-2-carboxylic acid [4-methoxy-7-(2-methyl-pyridin-4-yl)-benzothiazol-2-yl]-amide is synthesized from 5-methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide (260 mg, 0.60 mmol) and 2-methyl-4-trimethylstannanyl-pyridine (384 mg, 0.90 mmol) using the general procedure B as a light yellow solid in 50% yield. MS: m/e=396 (M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-f8e4b61f031348c78c9d5d901498eafb
Quelldatensatz
uspto-grants-2004_12
Patentnummer
US06835732B2

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