4-Methoxy-alpha-toluenethiol → 4-{[3-(Methyloxy)phenyl]amino}-6-({[4-(methyloxy)phenyl]methyl}thio)-3-quinolinecarboxamide

HRID 230861Notizen

Reaktionsgleichung

Cl.I[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([NH2:15])=[O:14])=[C:6]2[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=1.CC(C)([O-])C.[K+].[CH3:31][O:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][SH:40])=[CH:35][CH:34]=1.O(C1C=CC=CC=1P(C1C=CC=CC=1)C1C=CC=CC=1)C1C=CC=CC=1P(C1C=CC=CC=1)C1C=CC=CC=1>CN(C)C=O>[CH3:24][O:23][C:19]1[CH:18]=[C:17]([NH:16][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([S:40][CH2:39][C:36]4[CH:37]=[CH:38][C:33]([O:32][CH3:31])=[CH:34][CH:35]=4)[CH:4]=3)[N:9]=[CH:8][C:7]=2[C:13]([NH2:15])=[O:14])[CH:22]=[CH:21][CH:20]=1

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

Intermediate 14 (0.020 g), potassium tert-butoxide (0.0061 g) and [4-(methyloxy) phenyl]methanethiol (available from Aldrich) (0.007 ml) were added to a stirred solution of tris(dibenzylidineacetone)dipalladium(0) (0.002 g) and (oxydi-2,1-phenylene)bis (diphenylphosphine) (0.002 g) in N,N-dimethylformamide (1.5 ml), and the mixture was heated under microwave irradiation at 60° C. for 8 min. The solvent was evaporated in vacuo, and the residue purified by Mass Directed Preparative HPLC (Method A) to give the title compound (0.0048 g).

Aufarbeitung

customThe solvent was evaporated in vacuo
customthe residue purified by Mass Directed Preparative HPLC (Method A)

Quellen und Nachweise

ORD-Eintrag: ord-28ee6ea5069f418aae92f3f69428b049
Quelldatensatz: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07566786B2

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