Hydrochloric Acid → 2-Carboxy-4-methoxy-3-(2-phenylethyl)benzo[b]thiophene

HRID 230883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 230883
[CH3:1][O:2][C:3]1[C:11]2[C:10]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:9]([C:20]([O:22]C)=[O:21])[S:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.CO.[OH-].[Na+].Cl>O1CCCC1>[C:20]([C:9]1[S:8][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[C:10]=1[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([OH:22])=[O:21]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 231035484-Methoxy-2-methoxycarbonyl-3-(2-phenylethyl)benzo[b]thiophene

Produkt 1

HCID 231035202-Carboxy-4-methoxy-3-(2-phenylethyl)benzo[b]thiopheneAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-methoxy-2-methoxycarbonyl-3-(2-phenylethyl)benzo[b]thiophene (1.09 g) in tetrahydrofuran (6 mL)-methanol (21 mL) was added 1 mol/L aqueous sodium hydroxide solution (21 mL), and the mixture was heated for reflux for 3.5 hours. The reaction mixture was cooled to room temperature. To the mixture was added 2 mol/L hydrochloric acid (11 mL), and the precipitated crystals were collected by filtration. The crystals were dried under reduced pressure to give the title compound (1 g).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperaturefor reflux for 3.5 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. customThe crystals were dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-577da371a756430ebeb9460efc8effec
Quelldatensatz
uspto-grants-2009_07
Patentnummer
US07566699B2

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