1-(2-Hydroxyethyl)piperazine → 2-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanol

HRID 2309032

Reaktionsgleichung

Reaktionsgleichung von HRID 2309032
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>C(O)C>[OH:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][N:17]([CH2:7][C:6]2[CH:9]=[CH:10][C:3]([S:2][CH3:1])=[CH:4][CH:5]=2)[CH2:16][CH2:15]1

Komponenten

5

Edukt 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 8471TriethylamineHCID 701281-(Chloromethyl)-4-(methylthio)benzene

Produkt 1

HCID 20575972-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]ethanolAusbeute 71,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(methylthio)benzyl chloride (28.6 g), 1-(2-hydroxyethyl)piperazine (21.6 g), triethylamine (16.8 g), and ethanol (250 ml) is stirred at room temperature for 5 hours. The ethanol is then removed in vacuo and water added to the residue. The product is extracted with ether, dried, and the ether evaporated to give 31.6 g of 1-(2-hydroxyethyl)-4-[4-(methylthio)benzyl] piperazine as an orange oil, suitable for use in the next reaction.

Aufarbeitung

  1. customThe ethanol is then removed in vacuo and water
  2. additionadded to the residue
  3. extractionThe product is extracted with ether
  4. customdried
  5. customthe ether evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5e33a732aad4425ba516fd9cf0aaad75
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04692448

Verknüpfte Notizen

Wird geladen…