Bacitracin → HCID 86741792, Verbindung

HRID 2309220

Reaktionsgleichung

Reaktionsgleichung von HRID 2309220
[Co:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24].[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:110])[CH3:109])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49]>CO>[CH3:46][CH2:47][C@@H:48]([C@@H:50]1[NH:81][C:79](=[O:80])[C@@H:78]([CH2:82][CH2:83][CH2:84][NH2:85])[NH:77][C:75](=[O:76])[C@@H:74]([NH:86][C:87]([C@@H:89]([NH:94][C:95]([C@H:97]([NH:103][C:104]([C@@H:106]([NH:111][C:112]([C@H:114]2[N:118]=[C:117]([C@@H:119]([NH2:124])[C@H:120]([CH2:122][CH3:123])[CH3:121])[S:116][CH2:115]2)=[O:113])[CH2:107][CH:108]([CH3:109])[CH3:110])=[O:105])[CH2:98][CH2:99][C:100]([OH:102])=[O:101])=[O:96])[C@H:90]([CH2:92][CH3:93])[CH3:91])=[O:88])[CH2:73][CH2:72][CH2:71][CH2:70][NH:69][C:67](=[O:68])[C@H:66]([CH2:125][C:126]([NH2:128])=[O:127])[NH:65][C:63](=[O:64])[C@@H:62]([CH2:129][C:130]([OH:132])=[O:131])[NH:61][C:59](=[O:60])[C@H:58]([CH2:133][C:134]2[NH:138][CH:137]=[N:136][CH:135]=2)[NH:57][C:55](=[O:56])[C@@H:54]([CH2:139][C:140]2[CH:141]=[CH:142][CH:143]=[CH:144][CH:145]=2)[NH:53][C:51]1=[O:52])[CH3:49].[Co:1].[CH3:2][CH2:3][C@@H:4]([C:25]([C@H:27]([C@@H:29]([OH:45])[C@H:30]([C@H:32]1[O:37][C@@H:36]([CH2:38][C:39]([O:41][OH:42])=[O:40])[C@H:35]([CH3:43])[CH2:34][C@@H:33]1[CH3:44])[CH3:31])[CH3:28])=[O:26])[C@H:5]1[O:9][C@@:8]([C@:11]2([OH:23])[O:15][C@@:14]([C@@H:18]([OH:21])[CH2:19][CH3:20])([CH2:16][CH3:17])[CH2:13][C@H:12]2[CH3:22])([CH3:10])[CH2:7][C@@H:6]1[CH3:24]

Komponenten

4

Edukt 2

HCID 10909430Bacitracin2×HCID 86741793Cobalt lysocellin

Produkt 1

HCID 86741792HCID 86741792, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1.3 grams (g) of cobalt lysocellin prepared as described in Example A, in 25 ml of methanol was stirred while 1.5 g of regular (reg) bacitracin (reg) was added thereto. Stirring was continued until solution of the bacitracin was complete. The reaction mixture was agitated at room temperature until precipitation of the complex occurred. The complex was isolated and recrystallized from methanol (10 ml/g) to obtain rod-like crystals.

Aufarbeitung

  1. additionwas added
  2. stirringThe reaction mixture was agitated at room temperature until precipitation of the complex
  3. customThe complex was isolated
  4. customrecrystallized from methanol (10 ml/g)
  5. customto obtain rod-like crystals

Quellen und Nachweise

ORD-Eintrag
ord-7568240176ab4fe9a41c79c6ecb477d4
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04693992

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