Thionyl Chloride → 3-(2-chloroethyl)-1-methyl-2,4(1H,3H)-quinazolinedione
Reaktionsgleichung
O[CH2:2][CH2:3][N:4]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH3:15])[C:5]1=[O:16].S(Cl)([Cl:19])=O>ClC(Cl)Cl>[Cl:19][CH2:2][CH2:3][N:4]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH3:15])[C:5]1=[O:16]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 4.5 parts of 3-(2-hydroxyethyl)-1-methyl-2,4(1H,3H)-quinazolinedione, 8 parts of thionyl chloride and 75 parts of trichloromethane was stirred and refluxed for 5 hours. The reaction mixture was evaporated, yielding 4.5 parts (95%) of 3-(2-chloroethyl)-1-methyl-2,4(1H,3H)-quinazolinedione as a residue (intermediate 171).
Aufarbeitung
- temperaturerefluxed for 5 hours
- customThe reaction mixture was evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-00e83f0e0a674b1fb7c9717641f90c6a
- Quelldatensatz
- uspto-grants-1987_09
- Patentnummer
- US04695569
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