Hydrochloric Acid → Pyridine, 3-(3-chloropropyl)-, hydrochloride
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9]O)[CH:2]=1.P(Cl)(Cl)([Cl:13])=O.[ClH:16]>C(OCC)(=O)C.[OH-].[Na+]>[ClH:13].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][Cl:16])[CH:2]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
3-(3-Pyridyl)propyl chloride hydrochloride was prepared in quantitative yield by reacting 3-(3-pyridyl)propanol with phosphorus oxychloride in ethyl acetate at reflux temperature. The free base was generated by dissolving the hydrochloride in a 10% sodium hydroxide solution and extracting with an organic solvent (toluene or ether).
Aufarbeitung
- temperatureat reflux temperature
- extractionextracting with an organic solvent (toluene or ether)
Quellen und Nachweise
- ORD-Eintrag
- ord-65cf91a57628444487d9d93d49435361
- Quelldatensatz
- uspto-grants-1987_09
- Patentnummer
- US04696920
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