Ibuprofen, (+-)- → Ibuprofen codeine
Reaktionsgleichung
[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.[OH:23][C:24]([CH:26]([C:28]1[CH:37]=[CH:36][C:31]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:25]>>[OH:25][C:24]([CH:26]([C:28]1[CH:29]=[CH:30][C:31]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:36][CH:37]=1)[CH3:27])=[O:23].[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1Komponenten
3
Versuchsvorschrift
Codeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry mixed. Water was then added and the mixture was granulated to form pharmaceutical, codeine containing granules. Starch 1500 was then mixed with the granules. Finally the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bi-layer tablet with a crushing strength of 11-12 kp.
Aufarbeitung
- dry with materialCodeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry
- additionmixed
- additionWater was then added
- customto form pharmaceutical