Potassium Carbonate → 4'-(12-Bromododecyloxy)biphenyl-4-carboxylic acid ethyl ester

HRID 231015

Reaktionsgleichung

Reaktionsgleichung von HRID 231015
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2].[Br:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][Br:19])=[CH:16][CH:17]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 187661,12-DibromododecaneHCID 4049156Ethyl 4'-hydroxy-4-biphenylcarboxylate

Produkt 1

HCID 539084014'-(12-Bromododecyloxy)biphenyl-4-carboxylic acid ethyl esterAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

An acetone solution of 90 m moles(21.8 g) of the above 4'-hydroxybiphenyl-4-carboxylic acid ethyl ester, 0.15 mole(49.2 g) of 1,12-dibromododecane, and 0.4 mole(55.3 g) of potassium carbonate was refluxed for four hours. The reaction sloution was filtered. The filtrate was concentrated, and then purified by column chromatography, to obtain 29.5 g of 4'-(12-bromododecyloxy)biphenyl-4-carboxylic acid ethyl ester [m.p. 88.6°-90.5° C⟧ (yield: 67%)

Aufarbeitung

  1. filtrationThe reaction sloution was filtered
  2. concentrationThe filtrate was concentrated
  3. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-0bb33560fb31420c98141f2a6085e2c6
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04844835

Verknüpfte Notizen

Wird geladen…