2-(Bis(methylsulfanyl)methylidene)propanedinitrile → 5-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazole

HRID 231038

Reaktionsgleichung

Reaktionsgleichung von HRID 231038
[C:1]([C:3]([C:9]#[N:10])=[C:4]([S:7][CH3:8])SC)#[N:2].[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[CH2:16][NH:17][NH2:18]>C(O)C>[F:11][C:12]([F:22])([F:23])[C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[CH2:16][N:17]1[C:1]([NH2:2])=[C:3]([C:9]#[N:10])[C:4]([S:7][CH3:8])=[N:18]1

Komponenten

4

Edukt 2

HCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrileHCID 599698((3-(Trifluoromethyl)phenyl)methyl)hydrazine

Produkt 1

HCID 140710225-Amino-4-cyano-3-methylthio-1-(3-trifluoromethylbenzyl)-pyrazoleAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

8.5 g of 1,1-dicyano-2,2-bis-(methylmercapto)-ethylene and 9.5 g of 3-trifluoromethyl-benzylhydrazine are mixed in 100 ml of ethanol. The mixture is stirred for 15 hours at 20° C. and the solvent is evaporated in a rotary evaporator. The residue is triturated in petroleum ether. 12.4 g (80% of theory) of 1-(3-trifluoromethylbenzyl)-3-methylmercapto-4-cyano-5-amino-pyrazol of melting point 142° C. are obtained.

Aufarbeitung

  1. customthe solvent is evaporated in a rotary evaporator
  2. customThe residue is triturated in petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-2bb6033b34274278a7fe1a46953b216c
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04845089

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