2,5-Difluorophenylacetic acid → N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

HRID 23104Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 23104
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])[CH:14]([CH3:16])[CH3:15]

Komponenten

3

Edukt 2

HCID 5228232,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Produkt 1

HCID 22894969N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

Versuchsvorschrift

Following General Procedure BI above, and using 2,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Quellen und Nachweise

ORD-Eintrag
ord-d51731c063b34a5f8ec81af0c1b7324a
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06849650B2

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